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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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32 hot topic(s) found with the query "Folate or folic acid"

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation
TT Hoang et al, EBiomedicine, January 9, 2024 (Posted: Jan 10, 2024 8AM)

From the abstract: "Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of differential methylation from in utero smoking exposure, and effects of environmental tobacco smoke (ETS). We meta-analysed data from up to 15,014 adults across 5 cohorts with DNA methylation measured in blood using Illumina's EPIC array for current smoking (2560 exposed), quit < 1 year (500 exposed), in utero (286 exposed), and ETS exposure (676 exposed). We also evaluated the interaction of current smoking with sex or diet (fibre, folate, and vitamin C)."

Folate Pathway Gene Single Nucleotide Polymorphisms and Neural Tube Defects: A Systematic Review and Meta-Analysis
AK Al Mekkawi et al, J Per Med, September 28, 2022 (Posted: Sep 30, 2022 7AM)

We reviewed the literature for all papers discussing both NTDs and SNPs in the folate pathway. Data were represented through five different genetic models. Quality assessment was performed using the Newcastle–Ottawa Scale (NOS) and Cohen’s Kappa inter-rater coefficient assessed author agreement. Fifty-nine papers were included. SNPs in MTHFR, MTRR, RFC genes were found to be highly associated with NTD risk. NOS showed that high quality papers were selected, and Kappa Q-test was 0.86. Our combined results support the notion that SNPs significantly influence NTDs across the population, particularly in Asian ethnicity.

Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate
KH van der Pol et al, EJHG, September 2, 2022 (Posted: Sep 02, 2022 9AM)

This guideline describes the gene-drug interaction of ABCG2 with allopurinol, HLA-B with allopurinol, MTHFR with folic acid, and MTHFR with methotrexate, relevant for the treatment of gout, cancer, and rheumatoid arthritis. A systematic review was performed based on which pharmacotherapeutic recommendations were developed.

MTHFR Gene and Folic Acid
CDC, February 2020 Brand (Posted: Feb 15, 2020 9AM)

Did results from a genetic test tell you that you have a methylenetetrahydrofolate reductase (MTHFR ) gene variant? You may have questions about what this means for your health, especially when it comes to your body’s ability to process folate.

Folic Acid Information
CDC, January 2020 Brand (Posted: Jan 05, 2020 11AM)

Folic acid is a B vitamin. If a woman has enough folic acid in her body before and during pregnancy, it can help prevent major birth defects of the baby’s brain and spine. Women need 400 micrograms (mcg) of folic acid every day.

Genetic Risk Factors for Folate-Responsive Neural Tube Defects.
Molloy Anne M et al. Annual review of nutrition 2017 Aug 269-291 (Posted: Jan 08, 2018 0PM)

Finding the genetic mechanisms of folate deficiency and neural tube defects-Leaving no stone unturned.
Au Kit Sing et al. American journal of medical genetics. Part A 2017 Nov (11) 3042-3057 (Posted: Jan 08, 2018 0PM)

MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies.
Yu Di et al. Italian journal of pediatrics 2017 Dec (1) 108 (Posted: Jan 08, 2018 0PM)

Folic Acid Supplementation for the Prevention of Neural Tube Defects US Preventive Services Task Force Recommendation Statement
USPSTF, JAMA, January 10, 2017 (Posted: Jan 12, 2017 3PM)

Plan Ahead: Folic Acid Can Help Prevent Certain Birth Defects
(Posted: Jan 12, 2017 3PM)

Bringing clarity to the role of MTHFR variants in neural tube defect prevention.
Stover Patrick J et al. The American journal of clinical nutrition 2015 Jun (6) 1111-2 (Posted: Jan 11, 2016 1PM)

Preconception folic acid use influences the follicle fluid proteome.
Twigt John M et al. European journal of clinical investigation 2015 Aug (8) 833-41 (Posted: Jan 11, 2016 1PM)

Can folic acid have a role in mitochondrial disorders?
Ormazabal Aida et al. Drug discovery today 2015 Nov (11) 1349-54 (Posted: Jan 11, 2016 1PM)

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.
Aarabi Mahmoud et al. Human molecular genetics 2015 Nov (22) 6301-13 (Posted: Jan 11, 2016 1PM)

Plan Ahead: Folic Acid Can Help Prevent Certain Birth Defects
Brand (Posted: Jan 11, 2016 1PM)

Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele.
Mazumdar Maitreyi et al. Birth defects research. Part A, Clinical and molecular teratology 2015 Sep (9) 754-62 (Posted: Oct 05, 2015 9AM)

Nutri-epigenomic Studies Related to Neural Tube Defects: Does Folate Affect Neural Tube Closure Via Changes in DNA Methylation?
Rochtus Anne et al. Mini reviews in medicinal chemistry 2015 (13) 1095-102 (Posted: Oct 05, 2015 9AM)

Findings from the National Birth Defects Prevention Study: Interpretation and translation for the clinician.
Alwan Sura et al. Birth Defects Res. Part A Clin. Mol. Teratol. 2015 Jun 25. (Posted: Jul 01, 2015 2PM)

Folic acid supplementation in pregnancy and implications in health and disease.
Barua Subit et al. J. Biomed. Sci. 2014 77 (Posted: Apr 27, 2015 6PM)

Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome.
Chango Abalo et al. Nutrients 2015 (4) 2748-2770 (Posted: Apr 27, 2015 6PM)

Primary prevention of congenital anomalies: recommendable, feasible and achievable.
Taruscio Domenica et al. Public Health Genomics 2015 (3) 184-91 (Posted: Apr 27, 2015 6PM)

WHO Guideline: Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects
April 2015 (Posted: Apr 27, 2015 6PM)

Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome.
Murto Tiina et al. Acta Obstet Gynecol Scand 2015 Jan (1) 65-71 (Posted: Mar 24, 2015 1PM)

Folate Supplements for Stroke Prevention - Targeted Trial Trumps the Rest
M Stampfer et al. JAMA< March 12, 2015 (Posted: Mar 16, 2015 1PM)

Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives: an epistasis analysis.
Wei L K et al. J Hum Hypertens 2015 Feb (2) 99-104 (Posted: Mar 16, 2015 9AM)

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
Keene Keith L et al. Front Public Health 2014 112 (Posted: Mar 16, 2015 9AM)

Association of Reduced Folate Carrier-1 (RFC-1) Polymorphisms with Ischemic Stroke and Silent Brain Infarction.
Cho Yunkyung et al. PLoS ONE 2015 (2) e0115295 (Posted: Mar 16, 2015 9AM)

Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in ChinaThe CSPPT Randomized Clinical Trial
Y Huo et al. JAMA, March 12, 2015 (Posted: Mar 16, 2015 9AM)

CDC Information: Optimal Blood Folate Concentrations for the Prevention of Neural Tube Defects
WHO Guideline at-a-glance Brand (Posted: Feb 25, 2015 0PM)

Pernicious Anemia
From NHLBI health topic site Brand (Posted: Jan 11, 2014 11AM)

What Is Pernicious anemia (per-NISH-us uh-NEE-me-uh) is a condition in which the body can't make enough healthy red blood cells because it doesn't have enough vitamin B12. Vitamin B12 is a nutrient found in some foods. The body needs this nutrient to make healthy red blood cells and to keep its nervous system working properly. People who have pernicious anemia can't absorb enough vitamin B12 from food. This is because they lack intrinsic (in-TRIN-sik) factor, a protein made in the stomach. A lack of this protein leads to vitamin B12 deficiency. Other conditions and factors also can cause vitamin B12 deficiency. Examples include infections, surgery, medicines, and diet. Technically, the term "pernicious anemia" refers to vitamin B12 deficiency due to a lack of intrinsic factor. Often though, vitamin B12 deficiency due to other causes also is called pernicious anemia. This article discusses pernicious anemia due to a lack of intrinsic factor and other causes. Overview Pernicious anemia is a type of anemia. The term "anemia" usually refers to a condition in which the blood has a lower than normal number of red blood cells. In pernicious anemia, the body can't make enough healthy red blood cells because it doesn't have enough vitamin B12. Without enough vitamin B12, your red blood cells don't divide normally and are too large. They may have trouble getting out of the bone marrow?a sponge-like tissue inside the bones where blood cells are made. Without enough red blood cells to carry oxygen to your body, you may feel tired and weak. Severe or long-lasting pernicious anemia can damage the heart, brain, and other organs in the body. Pernicious anemia also can cause other problems, such as nerve damage, neurological problems (such as memory loss), and digestive tract problems. People who have pernicious anemia also may be at higher risk for weakened bone strength and stomach cancer. Outlook The term ?pernicious? means ?deadly.? The condition is called pernicious anemia because it often was fatal in the past, before vitamin B12 treatments were available. Now, pernicious anemia usually is easy to treat with vitamin B12 pills or shots. With ongoing care and proper treatment, most people who have pernicious anemia can recover, feel well, and live normal lives. Without treatment, pernicious anemia can lead to serious problems with the heart, nerves, and other parts of the body. Some of these problems may be permanent. Other Names Pernicious anemia is one of two major types of "macrocystic" or "megaloblastic" anemia. These terms refer to anemia in which the red blood cells are larger than normal. (The other major type of macrocystic anemia is caused by folic acid deficiency.) Rarely, children are born with an inherited disorder that prevents their bodies from making intrinsic factor. This disorder is called congenital pernicious anemia. Vitamin B12 deficiency also is called cobalamin deficiency and combined systems disease.

Cerebral folate deficiency
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Hereditary folate malabsorption
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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